Abstract
In present study, an in vitro glycation model comprising both plasma and glucose designed to assess
glycation inhibitory potentials of N. sativa seed (NS) extracts. Plasma with several glucose quantities
in the presence of NS were incubated for thirty-five days at 37°C. Non-enzymatic glycation (NEG)
was quantified by Thiobarbituric acid technique. NEG levels were reduced by NS. Higher NS
concentrations significantly (P < 0.05) reduced the NEG demonstrating dose-dependent inhibitory
potential of NS. Plasma NEG levels were decreased up to 13% (P< 0.05). NEG inhibition correlated
(r=0.784) with NS concentrations. Present glycation inhibitory prospective of NS demands further
studies to determine the precise mechanism of action and effective dose of NS for therapeutic
interventions.
Hira Zafar, Fatma Hussai, Shoaib Zafar, Riffat Yasmin. (2013) GLYCATION INHIBITION BY NIGELLA SATIVA (LINN)–AN IN VITRO MODEL, Asian Journal of Agriculture and Biology, Volume 1, Issue 4.
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