Abstract
As the second prevalent cancer in women, breast cancer is a global epidemiologic problem and the medications used nowadays are not very effective being associated with undesirable complications.Due to the side effects of many chemical drugs, the use of natural drugs has increased dramatically over the past decade. This study aimed to investigate the toxicity of mint [Mentha piperita L. (Lamiaceae)] and tarragon (Artemisia dracunculus L.) hydroalcoholic extracts on MCF-7, Hu -02, T-47D, MDA-MB-231, and MCF-10A cell lines in vitro using the MTT assay. Extracted EOs (Essential Oils) were analyzed and identified by a GC/MS device. The effects of EOs from both plants at different concentrations (3, 7, 15, 30, 60, 125, and 500 µg/ml) were evaluated on the aforesaid cell lines for 24 h. The cytotoxicity effect was assessed by the MTT assay. The optical absorbance was measured by an ELISA system at 570 nm wavelength. Resultsindicated significant cytotoxicity of EOs from mint leave on growth of the breast cancer cell lines(MCF-7, T 47D, MDA-MB-231) and normal cell lines(MCF-10A, Hu-02) in a dose-dependent manner (P
