Abstract
Estimation of C-reactive protein (CRP) is widely considered for investigating the degree of inflammation especially in coronary heart disease (CHD) and ischemic stroke (IS). A variety of studies have been conducted. However, precise correlation of age-related hs-CRP levels with the severity of injury is not known. Hence, we carried out present study in age-matched (age range 55-66 years) female patients of ischemic stroke (IS), epilepsy (E), post-ischemic stroke epilepsy (pIS-E) and ischemic heart disease (IHD) and compared with the normal female control subjects (C). Group comparisons showed significant variations of hs-CRP (mg/L) for IS vs. C, E vs. C, pIS-E vs. C, IHD vs. C, IHD vs. E, E vs. IS and IHD vs. pIS-E and non-significant change for pIS-E vs. IS, IHD vs. IS and pIS-E vs. E, that revealed the role inflammation via change in hs-CRP not only in patients with ischemic disorders but also in epilepsy patients though the extent of increase in hs-CRP was quite less in epilepsy patients. Moreover, significant positive correlation of age and hs-CRP levels was revealed for the mentioned female patients with ischemic disorders and epilepsy. Conclusively, we investigated the role and involvement of hs-CRP in female patients with ischemic stroke, ischemic heart disease and post-ischemic stroke epilepsy and also in patients with epilepsy without apparent involvement of ischemic complications. Hence, inflammation seems a major factor causing atherosclerotic conditions in neurovascular and cardiovascular disorders.
