Abstract
Fish oil (FO) is a rich source of poly-unsaturated fatty acids (PUFAs). The present research aimed to evaluate the inhibitory potential of PUFAs from FO against enzyme monoamine oxidase B (MAO-B). The MAO-B enzyme is a target of interest for several neurological disorders because of its potential to oxidize dopamine and other neurotransmitters. Docking of PUFAs was performed to discover the binding mode and their interaction within the active site of MAO-B by using MolegroVirtual Docking (MVD) Software. The results show that docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) exhibit lowest docking score and form hydrogen bonds with Tyr 435, Tyr 326 and Gln 206, respectively. To the best of our knowledge, this is the first study describing the interaction of PUFAs with MAO-B. Our results demonstrate that PUFAs successfully interact with the active site residues that are known to have a key role in the enzyme’s catalytic activity, that are Tyr 435, Tyr 326 and Gln 206 thus, can be used as MAO-B inhibitors. Therefore, these PUFAs could help to normalize the levels of dopamine and other amine neurotransmitters in the brain. These findings are helpful in employing the use of FO for treating various neurological diseases linked with MAO-B’s increased activity. However, further preclinical studies will be required to validate the current findings.
