Abstract
The present study was made to describe the cellular changes in the liver of edible fish Lutjanus argentimaculatus (Forsk., 1775) of Karachi coast, infected with acanthocephalan parasites belonging to genus Serrasentis sp. For the pathological observation of infected liver, slides were made by routine microtomical procedure and studied under microscope. The architectural changes of tissues due to acanthocephala are being described by the selected photographs. Focal necrosis, fibrinoid homogenous masses, atrophy, cirrhosis as well as vascular degeneration were noted. Proboscis penetrated in the liver due to which hapatocytes become atrophied and necrosis extended up to maximum surface of liver.