Abstract
Although depressive disease is common in pregnant women, but it is always a risk in pregnancy and is tied to a high prevalence of maternal and postnatal mental health issues. The study was performed to compare the concentrations of serum serotonin, ghrelin and -aminobutyric acid (GABA) lab tests in third trimester with first trimester and second trimester. The study was performed in 28 pregnant women during their three trimesters as a cross-sectional case control study. Double-blind quantitative determination of serotonin, GABA, and ghrelin concentrations was performed using commercially available competitive enzyme-linked immunosorbent assay (ELISA) kits, according to manufacturer's protocol. The results of the 2 nd trimester showed significant raise throughout all hormones when compared to 1st trimester results, and showed the same significance when compared to the 3rd trimesters. On the other hand, the 3 rd trimester results showed significant increase level when compared to the 1 st trimester except for GABA hormone which increased insignificantly. In conclusion, this study suggested that the 2nd trimester involves in pregnancy-related complication secondary to mood and anxiety problems.
