Abstract
Diabetes mellitus is classified as type-1 diabetes mellitus (T1DM), type-2 (T2DM), gestational diabetes, and other specific types of diabetes mellitus. It is a group of complications or disorders leading to a variety of physiological, metabolic, physiochemical and behavioral alterations. Weight loss targets/ programs can be established with the important role of nurse practitioners in clinical practice since they have in-depth awareness of the research in diverse aspects of obesity/ weight management. Furthermore, overweight and obese conditions are alarming risk factors for most of the T2DM patients that requires the implementation of better primary care and all possible strategies. There are a variety of risk factors, causes and diverse issues in diabetes mellitus. The present review study was conducted to have better awareness in the cellular and molecular Pathophysiology of diabetes mellitus by studying the impact and interaction of leptin and adiponectin in patients having diabetic mellitus with/ without obesity. However, in view of controversial reports, further more detailed studies are required to understand the impact and role of adipocytokines and obesity in patients with diabetes mellitus. Conclusively, the present review provides opportunity for understanding the better knowledge of diabetic disorders.
