Abstract
Ischemic heart disease (IHD) or usually termed as myocardial ischemia is a group of clinical disorders/ syndromes that includes the chronic stable angina at one end and acute myocardial infarction on the other. Recent studies have taken a multidisciplinary and wider approach by investigating newer aspects for uncovering the mystery of the cause and cure of IHD. Obesity has been found profoundly involved as the causal factor for IHD. On the basis of a variety of studies and our own studies, we hypothesized that higher levels of plasma LDL-cholesterol (LDL-C), fibrinogen and homocysteine (Hcy) might be involved in disturbing the balance between the magnitude of injury and the capacity for repair, which may promote the progression of IHD with/ without obesity. There seems a significant role of Hcy, LDLC, and fibrinogen beside other changes in lipid and hematological profile. Significant correlations for the association of plasma fibrinogen, LDL-C and Hcy further explain the role of these important factors in regulating the ischemic heart disease with/ without obesity and vice versa. Conclusively, this review study helps for acquiring better understanding of the pathophysiology of ischemic heart disease.
