Abstract
The oxidative stress have been implicated in the pathogenesis of several diseases. It play a pivotal role in the pathophysiology of cancers. The aim of the current study was to explore the oxidative stress biomarkers in patients with different cancers. Two hundred and fifty different cancerous patients and fifty control subjects were recruited for the study after informed consent. Oxidative stress biomarkers including Xanthine Oxidase (XO), Nitric Oxide (NO), Malondialdehyde (MDA), Catalase (CAT), Superoxide Dismutase (SOD), Glutathione Reductase (GR) were estimated spectrophotometrically in blood samples. The correlation of oxidative stress biomarkers in different cancer was also analyzed. Significantly increased plasma levels of XO, MDA and NO and markedly decreased CAT, SOD and GR levels in plasma were observed in cancer patients. A strong positive correlations between MDA and SOD were observed in Multiple Myeloma (MM) patients, MDA and XO in Oral Cancer (OC) Patients. Furthermore in Colorectal cancer (CRC) patients NO and SOD have shown the direct correlation. While strong negative correlation was observed between NO and Catalase in Gastric Cancer (GC) patients. The study provides evidence of the relationship between oxidative stress biomarkers and different cancer, which could be used as diagnostic biomarkers for the individuals who are prone to cancer.
