Stressful experiences embrace complex correlation concerning body’s responses and brain function towards stress that leads to other psychological illnesses such as depression. Depression is a challenging provocative mental disorder with psychological and clinical consequence. Imipramine (IMI) is a tricycle antidepressant that constrains norepinephrine and serotonin reabsorption inside the synaptic cleft in the central nervous system and extensively prescribed to millions of depressive sufferers. Chronic stress models are considered as the most favorable and appropriate exemplar parallel to acute stress mockups for inspecting depression in experimental simulations. Reduced 5-Hydroxytryptamine and neuropeptide Y neurotransmission is significant in mediating depression provoked by chronic mild stress. The current study was intended to examine whether recurring administration of imipramine (1.0 mg/kg) may possibly attenuate the insufficiencies of behavior induced by chronic stress model in laboratory rats. Animals experiencing unpredictable chronic mild stress (UCMS) showed a significant hypophagia whereas, hyper-locomotive activity in activity box and open field and anxiolytic in light/dark transition box in imipramine administered groups of unstressed and stressed rats. Data indicates that Imipramine is efficacious in the attenuation of UCMS induced symptoms of depression in rats. Repeated administration of imipramine increased the activity in familiar and novel environment. Anxiolytic effect of Imipramine was higher in unstressed as compared to stressed animals. This study, therefore establish the stress and behavior scarcities relations and therapeutic approach of imipramine.
Muhammad Farhan, Hira Rafi , Hamna Rafiq. (2018) BEHAVIORAL EVIDENCE OF NEUROPSYCHOPHARMACOLOGICAL EFFECT OF IMIPRAMINE IN ANIMAL MODEL OF UNPREDICTABLE STRESS INDUCED DEPRESSION, , Volume 15, Issue 2.
