Abstract
Hypoglycemic activity of four selected plants extracts including seeds of Citrus limon, Citrus paradisi, Avena fatua and fruits of Withania coagulans were investigated in normal albino rabbits. The phytochemicals and minerals content of extracts were also analyzed. The experimental rabbits in fasting state were divided into different groups (6 animals/ group) including control (water 1ml/kg b.w.), negative control (0.05% dimethylsulphoxide 1ml/kg b.w.), positive control (glibenclamide 5 mg/kg b.w.) and test groups (200, 400 and 600 mg/kg b.w.) according to their organic and aqueous extracts treatments for oral glucose tolerance testing (OGTT). All the selected seeds and fruits extracts showed maximum presence of phytochemicals like alkaloids, flavonoids, phenols, saponins etc. along with trace minerals including Fe++, Zn++, Cu++, Na etc. OGTT showed the significant (p< 0.05) hypoglycemia after 30 minutes as compared to positive control. Fruits extracts of W. coagulans 200 mg (methanolic and aqueous) significantly (p
