Abstract
In view of diverse reports providing positive or negative role of adipocytokines in the progression of blood pressure leading to prehypertension and hypertension, and some of the controversial results, we planned to carry out comprehensive review of literature for understanding the role of some of the adipokines (adiponectin, leptin, resistin and apelin). Adipocytokines have cardioprotective properties in cardiovascular risk and disease. Higher leptin value is an independent predictor of peripheral artery disease in hypertensive patients . Hyperleptinemia is involved in endothelial dysfunction especially in hypertensive obese patients. Leptin levels were found to be higher in patients with uncontrolled hypertension compared to those with controlled hypertension, and hyperleptinemia was revealed as a predictor for arterial stiffness in hypertension patients. Some of the recent studies reveal adiponectin in obesity in relation to blood pressure, protection of incident hypertension by adiponectin independent of body fat, association of adiponectin with arteriolar vessel caliber in hypertensive subjects and hypertension associated with adiponectin polymorphism. Information provided in the current review indicates that further studies be conducted to understand the role and regulation of adipocytokines mainly in normal healthy people, people having blood pressure variations, and people with hypertension.
