Dopamine (DA) or 3, 4-dihydroxyphenethylamine is neurotransmitter involve in neurodegenerative disorder effecting through dopaminergic neurons of substantia nigra. Different herbs and herbal drug have great attraction to treat anxiety .Ginseng plant is a traditional plant use in china over two thousand year ago. Its use to cure many pharmacological condition .Its effects on neurotransmitter metabolisms. Recent study designed to observe the effect of GMVT on dopamine and its metabolites DOPAC concentration in whole brain of rats and anxiolytic effect of herb GMVT were analyzed by using light –dark box, elevated plus maze and open field box animal models. Data of present work show that GMVT exerts anxiolytic effect by increasing dopamine concentration in whole brain of rats.
