Vitamin D receptor (VDR) gene polymorphisms might play a role in the development of PCOS by exerting effects on LH, testosterone and sex hormone binding globulin (SHBG) concentration. VDR gene is highly polymorphic and several VDR polymorphisms have been recognized but the most commonly studied VDR variants are Fok1, Taq1 and Apa1. Therefore, present study was first of its kind to address the association of VDR gene polymorphism in PCOS among Pakistani females. It is a case control study consists of 150 women diagnosed with PCOS on the basis of Rotterdam criteria and 100 healthy participants. Genomic DNA was extracted through salting out method and VDR genotyping was done by PCR-RFLP analysis. Statistical analysis was conducted by SPSS (version 22) considering
Soubia Mallick, Mehir un Nisa Iqbal, Taseer Ahmed Khan. (2017) GENETIC POLYMORPHISMS OF VITAMIN D RECEPTOR IN POLYCYSTIC OVARIAN SYNDROME: A CASE CONTROL STUDY, , Volume 14, Issue 2.
