Abstract
Obesity is considered as an epidemic pathology. The present study hypothesized that Peroxisomes proliferator activated receptor gamma agonist (Rosiglitazone) would be beneficial to ameliorate the oxidative stress and Insulin resistance associated with the dysregulated carbohydrate metabolism in High fat diet induced obesity. Male Wistar rats (180-220 g body weight) were categorized into three groups. Group 1: Control animals remain fed on a normal rat diet, Group 2: High fat diet fed obese group, Group 3: Obese + RSG treated group, treated with Rosiglitazone (RSG) (2 mg/kg) for 7 days. The Obese model was developed using a high fat diet over a period of 8 weeks. Anthropometric parameters were determined; Tissues Malondialdehyde (MDA), Catalase (CAT) and Superoxide dismutase (SOD) assessed as markers of oxidative stress and serum Insulin level and HOMA-IR were assessed as a marker for Insulin resistance. Obese treated group showed a significant decrease tissue Malondialdehyde formation, while the activities of the antioxidant enzymes such as Catalase and superoxide dismutase were enhanced significantly, FBG, serum insulin level and HOMA-IR score were markedly decreased compared with untreated counterparts. The results suggested that oxidative stress and Insulin resistance mediated by HFD is restored by using PPAR- agonist.
