Abstract
Background: Urinary tract infections are one of the most common infections especially in young adults. Due to increase in fluoroquinolones use, empirical therapy in uncomplicated urinary tract infections with this group is now controversial. This study was aimed to see the efficacy of nitrofurantoin, ciprofloxacin and cotimoxazole (trimethoprim-sulphamethaxazol); the three most common drugs which can be used orally.
Materials & Methods: This descriptive study was carried out at the Department of Microbiology, Combined Military Hospital, Quetta, Pakistan from Januery 2014 to June 2014. A total of 270 urinary isolates (Outdoor 132, indoor 138) were cultured from urine specimens during the study period. Identification of isolates were performed by conventional methods and by using API 10S (Biomerieux, France). All the isolates were tested against nitrofurantoin, ciprofloxacin and cotimoxazole (trimethoprim-sulphamethaxazol) along with other routine antibiotics used for urinary pathogens.
Results: Out of total 270 urinary isolates, Escherichia coli was the dominant isolate cultured in 158 (58.51%) cases, followed by Klebsiella pneumonia in 48 (17.77%) and enterococcus spp. In 16 (5.92%) cases. Out of total 132 outdoor isolates, percentages of sensitivities of nitrofurantoin, ciprofloxacin and cotimoxazole were 92.4, 47.1 and 62.1 respectively. In case of total 138 indoor isolates, percentages of sensitivities for these three drugs were 84.0, 34.7 and 28.9 respectively.
Conclusion: Nitrofurantoin is very effective against both outdoor and indoor urinary isolates and can be used empirically for uncomplicated urinary tract infections.
Luqman Satti, Viqar Ashraf. (2014) IN-VITRO EFFICACY OF NITROFURANTOIN, CIPROFLOXACIN AND COTRIMOXAZOLE AGAINST VARIOUS URINARY ISOLATES, Gomal Journal of Medical Sciences , Volume 12, Issue 4.
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