Abstract
Background: Nitric oxide is involved in diverse physiological and pathological conditions, including those of the female reproductive tract. As it has a very short half-life, it is measured as nitrate-nitrite ratio. This study was aimed to assess the interrelationship between the fluctuating levels of estrogen, progesterone and serum nitrate-nitrite ratio in different phases of menstrual cycle measured in healthy females of reproductive age group.
Material & Methods: In this cross-sectional study, blood samples were collected from 71 healthy female volunteers on 3rd, 14th and 28th day of menstruation. The serum estradiol and progesterone were measured by ELISA and nitrate-nitrite ratio by the cadmium reduction method.
Results: Statistics revealed a significant rise (p<0.05) of the nitrate-nitrite ratio along with estrogen. There was also a considerable rise in progesterone in the follicular phase which fell off abruptly with ovulation. But no such rise in the nitrate-nitrite ratio was observed in the luteal phase.
Conclusion: The increase in ratio was analogous to the fluctuations in estrogen throughout the cycle, but no such significant relation with progesterone was observed.
Sharmistha Chatterjee, Mousumi Mukhopadhyay. (2015) ASSESSMENT OF RELATIONSHIP OF CIRCULATING NITRATE-NITRITE RATIO WITH FEMALE SEX STEROIDS IN DIFFERENT PHASES OF MENSTRUAL CYCLE, Gomal Journal of Medical Sciences , Volume 13, Issue 2.
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