Abstract
Lead is considered one of the wide spread environmental pollutants in Iraq.
Nowadays, some types of algae can be the solution by utilizing them as natural
medications to cure many diseases. This scientific article is intended to examine
spirulina action as an antioxidant to cure lead acetate induced injury in rats.
The total numbers of rats used were (48), the rats were divided into eight
groups, (42 rats) represented the treated group and 6 rats represented the control
group. 36 Rats of treated groups were injected initially with different
concentrations of lead acetate; while the rest 6 rats were only fed with Spirulina.
All our samples were examined by biochemical, hematological and
immunohistological methods. Our experiments proved that Spirulina had an
antioxidant action which can support the body defense system.
Malondialdehyde (MAD), Superoxide Dismutase (SOD) and Catalase (CAT)
were increased in lead injected group; while they decreased in the spirulina fed
group. There was a significant enhancement in lipid profile values of treated
group that were fed spirulina. In addition, it noticed that the values of aspartate
aminotransferase (AST) and alanine aminotransferase (ALT) in rats injected by
lead, then fed spirulina were decreased; this decrement was evidence in the
histological results. Moreover, the hematological results of rats fed with
spirulina appeared that the leukocyte and platelet numbers also decreased;
while the erythrocyte, hemoglobin, and hematocrit levels were increased,
unlike, rats injected with only lead.
The conclusion was that Spirulina ability to do obvious decrement in the
poisonous action of lead was done by its scavenger free radical activity and its
effective antioxidant activity.
Thura Alyasiri, Salah Alchalabi, Ithar AlMayaly. (2018) In vitro and In vivo antioxidant effect of Spirulina platensis against Lead induced toxicity in rats, Asian Journal of Agriculture and Biology, Volume 6, Issue 1.
-
Views
680 -
Downloads
131
Article Details
Volume
Issue
Type
Language
