Abstract
Leptin is an adipocytokine produced mainly in white adipose tissues though also produced in the brown adipose tissues and in a variety of body organs. It is 167-amino acid protein present in our body in free form and bound with proteins. Leptin is involved in the pathogenesis of hypertension and cardiovascular diseases, regulates food intake and energy expenditure and fat stores and helps performing several other physiological and pathophysiological processes. Some of the recent studies in human and animal studies explain the involvement of leptin in hypertension. However, most of the information about leptin-sympathetic and leptin-resistance actions has been predicted on the basis of in vitro and animal studies, and hence, it is essential to have data from human studies.
