The aim of this study was to examine whether an association exists between glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) genes polymorphism and severe oligozoospermia. Blood samples from patients and healthy individuals were collected and used for isolation of genomic deoxyribonucleic acid (DNA). The polymorphisms were analyzed using multiplex-polymerase chain reaction (multiplex-PCR) technique. Data were analyzed using Chi-square, Fisher exact test and independent t-test, as appropriate. The frequency of GSTT1 and GSTM1 null genotypes was observed to be higher in infertile men with severe oligozoospermia 41.18% and 27.45% in comparison with 13.46% and 9.62% in the fertile men, respectively.
Elahe Fatahi, Kyumars Safinejad, Mohammadreza Mehrabi. (2016) ASSOCIATION OF GLUTATHIONE S-TRANSFERASE M1 AND T1 POLYMORPHISMS WITH SEVERE OLIGOZOOSPERMIA, , Volume 13, Issue 1.
