Abstract
Diabetes mellitus is a very rapidly increasing morbid syndrome that is getting highly prevalent day by day. It is necessary to find its causes, new and improved treatments, and discovering novel pharmaceutical and molecular medicine based therapeutics for this disease. Animal models are the most promising way to study disease mechanisms and therapeutic compounds for diabetes and for drug assessment before human trials. Several strains of mice are currently being used in diabetes research, so having knowledge of the appropriate strain and model is crucial to get reliable results. In the current review, we summarize a comprehensive knowledge about the most commonly used mouse strains in diabetes research. Moreover, we also comment on different mouse strains and models that could be better for any particular type of study.
