Abstract
Foot and mouth disease (FMD) is a highly contagious disease mostly caused by
serotype A, O, and Asia-1 of virus that is endemic in Pakistan. FMD Serotype ‘O’ is
responsible for more than 60% of outbreaks in Khyber Pakhtunkhwa Pakistan. During
the present study, a total of 50 samples of FMDV serotype ‘O’ virus were selected from
field outbreaks samples preserved at the center. The nucleotide sequences of the VP1
coding region from all the virus samples were determined. The phylogenetic analysis
of FMDV serotype ‘O’ viruses circulating in different areas of Khyber Pakhtunkhwa
Pakistan was determined. This indicated continuous mutation from 2012 to 2015 due to
the presence of two different sub lineages within ‘O’ PanAsia-II lineage. The current
study reveals that the presences of two different sub lineages of FMDV O PanAsia-II
were identified which are circulating in different regions of Khyber Pakhtunkhwa
Pakistan. The emergence of new variants are possibly responsible for the failure of
vaccine in the country and creates hindrances in the control of disease in the region.
Hanif Ur Rahman, Mirza Ali Khan, Faiza Ashraf, Sibghat Ullah, Bait Ullah, Dost Muhammad Khan, Said Sajjad Ali Shah. (2018) Emergence of new variants in foot and mouth disease virus serotype ‘O’ in Khyber Pakhtunkhwa-Pakistan, 2012 to 2015, Asian Journal of Agriculture and Biology, Volume 6, Issue 2.
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