Abstract
Osteoporosis is a world wide well known metabolic bone disease featured as vulnerable fracture fragility associated by dropped bone mass.. Ageing female Albino rats were used in this experiment in order to detect changes and effects of the applied medicines; An image analytical method was designed for the metamorphic measurements regarding cancellous and cortical compact bony fraction. The transitional evaluation was studied from cancellous to compact through light microscopy,the effects of treatment of tamoxifen and nandrolonedecanoate were also analysed. The distance was taken from area of transition to peripheral rim/periosteum for compact bone and similarly trabeculi were also mapped out, thus their respective width/thickness was calculated statistically,several points in terms of area of interest (multiple discrete zones) explored through an individual bone cross section and comparative matching was done between the groups and found to have significant difference of cortical thickness in case of combination therapy treated group versus the other groups.
