Abstract
Diabetes is a chronic metabolic disorder and characterized by high blood glucose
level that defects in secretion of insulin. Oxidative stress and excess of free radicals
have been documented in diabetes occurrence. Curcuma mangga Val. is one of
traditional medicine that has potency for diabetic treatment.
The present study was conducted to evaluate the antidiabetic and antioxidant effects
of Curcuma mangga Val extract (CME) and fractions. In this study, the antioxidant
activity of four fractions of CME (water, hexane, ethyl acetate, and butanol fraction)
were measured using nitrite oxide (NO) and H2O2-scavenging activity assay, while
antidiabetic activity of those fractions were measured by α-glucosidase activity assay.
These fractions were also compared to antidiabetic drug, namely acarbose. In the NOscavenging activity, the butylated hydroxytoluene (BHT) had the highest activity
(IC50 69.75 µg/mL) compared to all fractions of CME and acarbose (ACR). Ethyl
acetate fraction of C. mangga extract (EACM) showed the highest in H2O2-
scavenging activity (IC50 162.78 µg/mL) compared to marker compound (BHT) (IC50
179.86 µg/mL) and other fractions. Hexane fraction of C. mangga (HCM) showed the
highest α-glucosidase inhibitory activity (IC50 182.45 µg/mL).
To conclude, the fractions of C. mangga extract could be used as an alternative in the
development of antioxidant and antidiabetic medicine.
Pujimulyani, Wisnu Adi, Rizal Rizal. (2018) Antidiabetic and antioxidant potential of Curcuma mangga Val extract and fractions, Asian Journal of Agriculture and Biology, Volume 6, Issue 2.
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