This research was undertaken to observe the subacute, subchronic and chronic effects of the neem oil on gonadal morphology and function after oral administration. Forty eight male albino rats were used in this daily for a period of three, six, twelve and twenty four weeks. The animals were administered with three different doses of neem oil orally The animals were divided in 4 different groups and each group was further divided into 4 subgroups o the basis of durations. Animals were sacrificed at the end of the experimental period. Testes were observed for gross and microscopic findings and the serum levels of Testosterone and gonadotrophins were studied This study records a dose and duration dependent morphological and functional suppression of male gonads in albino rats.
Zahid Ali Kaimkhani, S. Naeemul Hassan Naqvi , Masood Ahmed Shaikh, Naushin Malik. (2014) MALE GONADAL SUPPRESSION BY THE NEEM OIL AFTER SUB-ACUTE, SUBCHRONIC AND CHRONIC ORAL ADMINISTRATION OF NEEM OIL, , Volume 11, Issue 4.
