In this article a comprehensive review on pesticide poisoning in Pakistan’s perspective with reference to hospital records and studies with reference to impact of pesticide on health point of view is carried out. The consequences of these poisoning cases are discussed and future plan and strategies are briefly highlighted to tackle its implication on human health of occupational and non occupational groups. A concept of net working of laboratory for monitoring pesticides across Pakistan and a need of a regulatory body in the country is also emphasized for reliable monitoring assessment and reporting procedures in accordance with the appropriate environmental policies, laws and regulations in order to minimize the pesticides cases of poisoning as suggested in this article.