The ligand-based screening of the chemical compounds found in Glycyrrhiza glabra has been performed by Random forest modeling to search the inhibitors of xanthine oxidase, which has been implicated in oxidative injury to tissue and in many other diseases. The hits obtained by RF modeling are mostly flavonoids with Kumatakenin, Isoquercitrin and astragalin among the top of the list with 0.97, 0.96 and 0.95 RF score, and thus potentially be inhibitors of enzyme xanthine oxidase.
Sadaf Naeem, Erum Shireen, Khalida Bano, Dave J. Barlow. (2012) LIGAND-BASED SCREENING OF CHEMICAL CONSTITUENTS OF GLYCYRRHIZA GLABRA IN SEARCH OF INHIBITORS OF XANTHINE OXIDASE, , Volume 9, Issue 3.
