The present study was carried out to investigate the effect of benzene exposure on some hematological parameters and work related symptoms among workers of shoemaking units in Karachi. A total of 60 subjects (30 exposed and 30 control workers) in the age range of 20-55 years participated in the study. The results revealed a significant decrease in the erythrocyte account and hemoglobin levels among the exposed workers as compared to controls (P