Abstract
Occupational airways inflammation occurs when the bronchial tubes airways have
become swollen and oversensitive due to unwanted particles gases and particulate
matter of inorganic dust such as asbestos, silica and coal dust. Workers’ biomarker of
airways inflammation is used as tools to interpret their lung metabolism and toxic
mechanism reaction with pollutant exposed by industrial process. The aim of this
review is to determine compatible biomarker that is used in diagnosis occupational
airways inflammation from the exposure of inorganic dust. This review summarize the
outcome of workers’ biomarkers that indicate airways inflammation caused by
occupational exposure to the industrial pollutant. Relevance online database and data
from previous epidemiological studies have been used in this study. Previous study
found that Tumor Necrosis Factor-Alpha (TNF-α), Interleukin-6 (IL-6) and
Interleukin-8 (IL-8) in spontaneous sputum, induced sputum, nasal wash and
bronchoalveolar Lavage (BAL) have significantly correlate with symptoms of
occupational asthma among the workers. Few studies have examined on non-invasive
methods of EBC and FENO as biomarkers because of their reliability and sensitivity
screening tools to diagnosed occupational asthma by determined eosinophil level in
airway inflammation with a significant correlation of asthma severity. Several studies
of occupational asthma had also suggested the combination use of different biomarker
or pulmonary analysis such as lung function test for better results. Workers’
biomarkers indicate occupational disease regarding their airways inflammation and
guiding the clinician on decisions for further treatment. IL-6 and IL-8 mostly used as
the biomarker of occupational asthma to indicate the exposure of industrial pollutant.
Noor Haziqah Kamaludin, Juliana Jalaludin, Shamsul Bahri Mohd Tamrin, Abdah Md Akim. (2018) Biomarker of occupational airways inflammation for exposure to inorganic dust, Asian Journal of Agriculture and Biology, Volume 6, Special Issue.
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