Abstract
A pragmatic approach of human biological monitoring was used to measure the
exposure level, and examining the blood and urine metabolites (=exposure
biomonitoring) which is complemented by estimating the biological effects (=effect
biomonitoring). In this cross-sectional study, a total of 53 exposed machinists who
were exposed to chromium and nickel in working metal fluids were recruited. The
study aimed to determine the different genotoxic endpoints of the metalworking fluid
with chromium and nickel by considering the exposure-effect continuum approach.
Result showed that the mean values for both the personal air, blood and urine of
chromium and nickel concentrations exceeded the reference value. Linear regression
analysis showed that both blood and urine chromium is the significant factors for
micronuclei and comet tail length formation among machinists.
How Vivien, Hashim Zailina, Miswon Nurul Husna, Lokman Nur Naqibah, Hashim Nurul Maizur, Mohd Bashah Nursyahidah, Nasiruddin Lim Nur Sabrina. (2018) A pragmatic approach of genotoxic monitoring: the exposure-effect continuum of metalworking fluid with chromium and nickel among machinists at bearing manufacturing industry, Asian Journal of Agriculture and Biology, Volume 6, Special Issue.
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