Abstract
Elimination kinetics of cefaclor was investigated in twelve male healthy volunteers after 375 mg single dose oral administration of
the drug. Elimination kinetics parameters revealed that the mean value for rate constant (K10) was 0.30, mean value for elimination
half-life was 2.25h, mean value for rate constant (K21) was 0.30, mean value for clearance was 4.04 1/h, mean value for mean
residence time was 6.73h. No relation was found regarding age, weight, height and body temperature considering elimination
kinetics
