Striated muscles like the indirect flight muscles (IFM) of the Drosophila are made up of thick and thin filaments that slide pass each other to generate contraction. Many proteins are involved in the structure as well as the regulation of the muscles. The IFM of the Drosophila is used in many studies to understand the muscle regulation. The presences of IFM specific proteins/isoforms are thought to be of relevance to the specific structure and function of the IFM. heldup2 (hdp2 ) is a point mutation in the constitutive exon of troponin (Tn)-I gene, that shows effects in the structure and function of all the muscles including the IFM. We have created mutants in the lab, designated as 3A and 3D that were found to suppress the effects of hdp2 . In this research we are reporting the details of the molecular and behavioural analysis of the suppressor mutations and their affects on the TnI mutation hdp2 .
M. A. Ansari, Upendra Nongthomba, Mark Cummins, John Sparrow. (2007) A MUTATION IN THE TROPOMYOSIN GENE IS POSSIBLY RESPONSIBLE FOR SUPPRESSING THE EFFECTS OF TROPONIN-I MUTATION IN THE DROSOPHILA MELANOGASTER MUSCLES, , Volume 4, Issue 4.
