Abstract
This experiment was done to determine histopathological features of adult Ornithodorous lahoransis bite on rat. In this investigation adult male rats were infested with O. lahoransis ticks. Animals were divided into two groups and euthanized two days and two weeks after infestation. The skin samples were fixed in 10% buffer formal saline and processed and sections were stained with hematoxylin & eosin. The lesions reflected the clinical and gross findings, with hyperemia, edema and vacoulation in the early stages, cellular infiltrations, principally lymphocyte accompanied vascular changes. Newly formed fibrous tissue with large number of hyperemic capillaries and active inflammatory process in which lymphocytes and eosinophiles were the predominant cells were seen after two weeks. Foci of necrosis in the epithelium with remnant of infiltration of polymorphonucular cells with sever hemorrhages were also evident. Vascular changes included prevascular infiltration of lymphocyte and fibrinoied necrosis on the vessel walls.
