Abstract
There are many experimental methods of influencing the neuronal excitability and eliciting the convulsions in humans and animals. One of the major procedure or technique for inducing seizures in animals is kindling. In kindling the afterdischarges are elicited that later progress to generalized convulsions in an animal. There are a variety of reports documenting either low or high levels of blood sodium, potassium, calcium, glucose, cholesterol, total protein, blood hemoglobin etc. Blood calcium levels, however, are considered as important in the biochemical fluctuations occurring in epilepsy in humans and experimental animals. But no precise studies have yet been carried out to predict the pathophysiologic role of these factors in epilepsy. In the present work, changes in blood sodium, potassium, cholesterol, total protein, glucose, hemoglobin and other parameters were carried out in pentylenetetrazole (PTZ) induced kindled rabbit. The fluctuations are not significant when compared with the normal controls. But significant decrease in blood calcium levels in PTZ kindled male and female rabbit is evident in the present study. Hence, hypocalcemia might be considered as contributory factor for epilepsy. The results obtained in the present work provide a biochemical and hematological basis of control over the epileptogenic influences/ effects of the biomedical/ environmental agents. Conclusively, the present investigation in the hematobiochemical changes in a kindling model of epilepsy emphasizes to search through different angles the multifaceted role of calcium in epilepsy and other hyperexcitability conditions.
