Abstract
It is estimated that 50–100 million animals worldwide are used annually and subsequently killed in scientific procedures. The topic is controversial, with supporters and opponents arguing about ethical issues and whether using animal models is good or bad science. According to the U.S. Foundation for Biomedical Research (FBR), "animal research has played a vital role in virtually every major medical advancement of the last century for both human and animal health"and seven of the last ten Nobel Prizes for medicine have depended in part on animal research, though whether that aspect of the research was necessary is in question. It is now been voiced that use of other alternative techniques in place of animal models can be employed successfully that includes cell cultures, statistical interpretation of data and futuristic computer simulation models that could minimized the sufferings of animals. This paper deals with the both negative and positive aspects of animal models comparable to non animal studies and conclude that improvements in experimental methodology the suffering and pain of the animal can be reduced .