In this study farmers who grew cotton or vegetables were interviewed about their socioeconomic background, health status of family, and perception about the use of pesticides and health signs and symptoms and data were collected on a pre-designed questionnaire with closed and open questions. Respondents were randomly selected using a snowballing technique. The survey was conducted in District Nawabshah a cotton-growing area of Sindh, where heavy use of pesticides had been reported. Risk associated with pesticide to agricultural workers and the needs of epidemiological studies for the assessment and management in the country are discussed.