A retrospective study was carried out on formalin fixed paraffin embedded blocks of 50 out of 392 diagnosed cases of hyperplasia and
adenocarcinoma. The aim of this study was to compare the incidence of C erb-B2 Proto-oncogene over-expression in hyperplasia and
adenocarcinoma of endometrium. The 5μ thick sections made and stained with H & E for review and diagnostic typing and grading of
the cases. The immunohistochemical staining was done on sections using polycolonal rabbit anti erb-B2 ZYMED USA, and ZYMED
2
nd Generation Immunodetection system to observe oncoprotein over expression. The grades were distributed of erb-B2 over
expression in selected cases of adenocarcinoma was 66%, 66.66% and 75% for grade I, II and grade III respectively.
S. M. Hasan, Fauzia Imtiaz, S. Q. H. Naqvi. (2005) THE ROLE OF C erb-B2 PROTO-ONCOGENE OVER-EXPRESSION IN ENDOMETRIAL HYPERPLASIA AND ADENOCARCINOMA, , Volume 2, Issue 2.
