Abstract
Purpose: To analyze the intra vitreal Anti VEGF complications observing
different intravitreal injection protocols.
Study Design: This is an open label, prospective, multicenter cohort study.
Place and Duration of Study: The audit was conducted at five different
hospitals from September 2016 to March 2018.
Material and Methods: All intravitreal injections of Bevacizumab, Ranibizumab
and Aflibercept were included irrespective of the context of the injections.
Questions were asked in the designed proforma regarding use of povidone
iodine, sterile drapes, Opsite, speculum, sterilized instruments, pre-operative
and post-operative antibiotics. Data was also collected about scrubbing before
the procedure, use of cap and mask during the procedure and whether injection
was given in Operation Theater or in an office based setup. Complications,
whether systemic or ocular, were enumerated and their management was also
noted down.
Results: A total of 2,854 injections were given to 2,289 patients by 10 different
surgeons in 5 different institutes. There were 6 surgeons who did not prescribe
pre-operative antibiotics, 4 surgeons did not use cap and mask during the
procedure, while 2 surgeons did not use Opsite during the procedure. Office
based injections were given by 1 surgeon while all the others administered
injections in an operation theater. Complications included subconjunctival
hemorrhage, in 184 cases, sterile inflammation in 78 cases, transient rise in IOP
in 53 eyes and 1 case each of endophthalmitis, lens touch and retinal
detachment.
Conclusion: The ocular and systemic complications number is low and
comparative to the available literature after injecting different intra-vitreal anti
VEGF.
Hussain Ahmad Khaqan, Tariq Khan, Haroon Tayyab, Tariq Khan Marwat, Muhammad Qasim Lateef, Muhammad Tayyab. (2019) Complications of Different Intravitreal Anti VEGF Injections at Multiple Centers Observing Different Protocols, Pakistan Journal of Ophthalmology, Volume 35, Issue 1.
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