Studies were carried out to evaluate anticlostridial activity of Rasoot (crude aqueous extract of Berberis aristata seeds), Ajwain-khurasani (Hyoscyamus niger seeds), Neem (Azadiraclua indica leaves) and Bakain (Melia azedarach leaves). The results of ill vitro experiments have revealed that the aqueous extracts of these plant drugs do possess considerable antibacterial activity against Clostridium petfringens types Band D. The activity was comparable to standard discs of kanamycin and tetracycline. Preliminary ill vivo evaluation has indicated that Rasoot possesses potency to treat enterotoxaemia in the goats. It is conceivable that these plant drugs contain some active principles which exert anti clostridial activity both ill vivo and in vitro experiments.
