Interactions of combine indices (cutting and reel) with crop variety and grain moisture at harvest in relation to shattering loss of wheat and grain moisture were statistically significant at 5% level of probability. The results demonstrated that wheat recovered was 1.2 to 2.8% less as the grain moisture decreased from 24 to 15%. Crop variety also indicated a significant effect on the losses. Change in the reel as well as cutting indices had quadratic relationship with the shattering loss. Values of 1.25 and 2.00 were considered desirable for reel and cutting indices respectively with regard to minimization of harvesting losses.