Abstract
Pharmacokinetic parameters which describe the distribution and climination of oxytetracycline were investigated in 6 normal bectal goats following intravenous administration of a single dose (25 mg/kg). The disposition kinetics of the drug was described in terms of bi-exponential expression C, = A &t + BF ' Based on the oxytetracycline levels in plasma, the elimination half-life was 11.94 + 2.84 hours (mean + SEM). Total body clearance which is the sum of all clearance processes, was 3.15 + 0.38 I/kg. Based on these kinetic parameters, priming and maintenance doses at different timc intervals were suggested. The influence of disease conditions on the predicted plasma Icvels remains to be verified.

Tanweer Khaliq, Mahmood Ahmad, Qaiser Mahmood Khan. (1991) Disposition kinetics and urinary excretion of oxytetracycline in goats, , Volume 28, Issue 4.
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