Abstract
Pharmacokinetic parameters which describe the distribution and climination of
oxytetracycline were investigated in 6 normal bectal goats following intravenous
administration of a single dose (25 mg/kg). The disposition kinetics of the drug was
described in terms of bi-exponential expression C, = A &t + BF ' Based on the
oxytetracycline levels in plasma, the elimination half-life was 11.94 + 2.84 hours
(mean + SEM). Total body clearance which is the sum of all clearance processes,
was 3.15 + 0.38 I/kg. Based on these kinetic parameters, priming and maintenance
doses at different timc intervals were suggested. The influence of disease conditions
on the predicted plasma Icvels remains to be verified.
