Abstract
Anticestodal efficacies of total alkaloids and glycosides isolated from fruit-rinds of Funica u2.1pLitum (Anar) were studied in goats infected naturally with cestode infection. Both these isolates were administered separately at the dose rates of 75, 150 and 225 mg/kg body weight orally. A standard synthetic tapeworm ) remedy, Nilzan (Levamisole, 1.5 Dxyclozanide, 3 Z) was also given to a group. Pre-treatment and post-treatment faecal eggs per gram (EP )counts on 3rd, 10th and 15th days of the drug administration were determined in all the groups. Total glycosides of P. grital failed to exert a significant anticeatodal effect whereas total alkaloids reduced the EPG counts highly significantly (150.001) on day 15th at the doses of 150 mg and 225 mg/kg b.wt. However, significant (P<0.05) EPG reductions were also recorded on days 3rd and 10th at 150 mg/kg and 225 mg/kg doses while 75 mg/kg dose level produced a similar effect on day 15th only. The percentage EPG reductions at dose rates of 150 in and 225 mg/kg were statistically similar to that of the control drug, Nilzan(R) . Therefore, it is conceivable that alkaloids of P. ai:?!Lpqa are as potent as Nilzan"1}, against the cestode infection in goats and these data suggested that they could be at least in part reap:mg/1)1e for the anticestodal action of this indigenous plant drug.
