Abstract
Efficacy and safety of Quinapyrainine sulphate at different dosage levels, was studied using seven horses and eleven donkeys naturaVy infected with TrypeoTo.coma evar1.0,. The animals were divided into four groups. Groups I, 11 and Ill were given Quips,- PyrArnine sulphate subcu(aneousTy @ 2.0, 2.5 and 3,0 trigikg of body weight. respectively. Group 1Y was kept as infected untreated control. The study revealed that Quitapyrarnine sulphate was quite effective against Trypanosome evargul infection at a dosage level of 3.00 rng/kg body weight. Under-dosage of the drug may toad to drug resistance thereby resulting in relapse infections. Further, in view of the side effects, it is suggested that the total dose of the drug should net be given in one shot.
INTRODUCTION
TorPalansomiasis is an important zoonotic disease affecting almost all the nna.mrnals with variable intensity. This classical disease entity in the Indo-Pak sub-continent occurs in horses and is known as surra. Tt is nearly always fatal to horses if treatment k not applied (SouTsby, 1982). Various measures undertaken for the control of this disease include vector control, chemotherapy and vaccination. It is due to the problems. involved in maintaining vector control and the absence of effective vaccine that the livestock almost entirely depends on trypanocidal drugs, for prevention and treatment of trypa.ru)smnia.sis, The development or drug resistance in trypanosorna popoz, ,ions has further limited the choice of effective drugs available to veterinarian's and livestock owners. in Pakistan many drugs are used for the treatment surra but no authenticated data are avails.bIs regarding the efficacy and sarcr.q.7 of these drugs. The present study was, therefore, planned to deter-
