Abstract
Administration of different concentrations (500, 750, 1000, 1500 and 200(1 ppm) of potassium dichromate (K2Cr207) mixed in drinking water to adult mice, Mus musculus ad libitum for 8 weeks resulted in dose-related decreased body growth and reduced feed intake, during the first 4 weeks of administration. Chromium was accumulated in the liver in a dose dependent manner, accompanied by some hepatolobular derangements in the liver. Excessive chromium deposition, retarded body growth and hepatotoxicity as indicated by histological abnormalities indicate dichromate toxicity.
ASMATULLAH , MALIKA AZMAT NOREEN. (1999) EFFECT OF ORAL ADMINISTRATION OF HEXAVALENT CHROMIUM ON TOTAL BODY WEIGHT, CHROMIUM UPTAKE AND HISTOLOGICAL STRUCTURE OF MOUSE LIVER , Punjab University Journal of Zoology, Volume 14, Issue 1.
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