Isolated congenital hypoparathyroidism is a very rare entity. It has not been reported in Pakistani literature before; however it has been reported as part of various syndromes and autoimmune disorders. We are reporting two sisters who presented with seizures. Their workup revealed congenital hypoparathyroidism since neonatal period. We followed them for 6 and 3.5 years respectively and monitored their growth, development and screened for possible complications and association of hypoparathyroidism