Objective: To determine the accuracy of urine protein creatinine ratio with 24-hour urinary protein excretion in the diagnosis of childhood nephrotic syndrome. Study design: Cross-sectional study Place and duration of study: This study was conducted in Pediatric Nephrology ward and OPD, National Institute of Child Health, Karachi from 15th March 2011 to 14th September 2011. Material and Methods: Total 130 children aged 1 to 12 yrs who fulfilled the inclusion criteria were studied after taking the informed consent. The SPSS version 15 was applied to analyze the data. Results: Mean spot urine protein creatinine ratio was 14.3 ± 10 and 24 hours urine protein were 102.7 ± 54.6 mg/m2 /hr. Accuracy of spot urine protein creatinine ratio with 24 hour urinary UP in children with nephrotic syndrome was 118 (90.8%). Conclusion: Spot urine protein creatinine ratio is as accurate as 24 hour UP with the diagnostic accuracy of 90.8%.
