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Abstract
Objective: To compare the mean forced expiratory volume in 1 second with nebulized versus systemic corticosteroid therapy for management of children presenting with acute exacerbation of asthma. Study Design: Randomised controlled trial. Place and Duration of study: Pediatric Medicine Unit II, Mayo Hospital, Lahore from July to December 2017 Material and Methods: Total of 100 cases (50 cases in each group), age 5-12 years of either gender presenting with acute exacerbation of asthma were included. FEV1 was noted at baseline. In group A, children were given nebulized salbutamol (100µg every four hours for 48 hours) plus beclomethasone (40μg/kg every 12 hours, for one week, each dose contained 250µg). In group B, children were given nebulized salbutamol (100µg every four hours for 48 hours) plus injectable dexamethasone (0.6mg/Kg every 12 hours for one week). All patients were followed-up in OPD for 7 days. Both groups were compared for mean FEV1 by using independent sample t-test. Pvalue≤0.05 was considered as significant. Results: Children in group A had mean FEV1 significantly higher as compared to group B i.e. 119.54 vs. 104.94, p-value=0.000. and the same effect was seen in all age groups of patients, gender as well as for weight of children respectively. Conclusion: Nebulized corticosteroid is more effective in terms of better respiratory function than systemic corticosteroid for treating children with acute exacerbation of asthma

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UbaidUllah Khan , MUHAMMAD AZEEM SUBHANI, , MIMPAL SINGH, UbaidUllah Khan , MUHAMMAD AZEEM SUBHANI, , MIMPAL SINGH. (2020) Comparison of Nebulized Versus Systemic Corticosteroid for Management of Children Presenting with Acute Exacerbation of Asthma, , Volume 44, Issue 3.
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Pakistan Pediatric Journal
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Volume 44
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