Angioedema is a life-threatening reaction characterized by swelling of the face, lips, tongue or larynx. Known adverse effects of Pitavastatin do not include angioedema. We report first case of a 55-year-old Asian male developing post exposure angioedema to 2mg Pitavastatin. Note that the patient showed no history of hypersensitivity. Relationship between Pitavastatin and angioedema was assessed by Naranjo scale