67-year-old lady presented with the chief complaint of painful nodular ulcerative mixed red and white coloured lesion of the tongue from 8 months Personal history of the patient revealed that she has been smoking 10–12 cigarettes per day for 27 years. No systemic complications were found. Intra –oral examination revealed a leuco–erythro-plakic, non – scrapable lesion of the dorsum surface of the tongue extending to the right lateral border, measuring about 2×2 cm. [Figure-1] On palpation the lesion was indurated and soft to firm in consistency. A significant colour variegation in the lesion was found with the admix of white and red areas. Cervical group of lymph nodes of the patient was non-palpable. On the basis of clinical features, a provisional diagnosis of leucoplakia was given