Abstract
A 33 year old male presented with a painful non–healing growth of gingiva from eight months. Intra–oral examination revealed an indurated and erythematous lesion on gingiva with relation to tooth #29 to missing #30 measuring 2×1 cm. (Figure-1) Radiographic examination revealed a bone loss with relation to tooth #29 and #30. An incisional biopsy was performed and final diagnosis of peripheral ameloblastoma was given. At the time of excisional biopsy patient came up with increased swelling which remained ulcerated and the site of incisional biopsy was not healed. Histopathological examination of excisional biopsy showed numerous islands of basaloid cells budding off from the basal cell layer of epithelium.(Figure-2) These islands comprised of numerous apoptotic cells and mitotic figures. The peripheral cells of the islands demonstrated a palisaded arrangement. These features were similar to peripheral ameloblastoma, (PA)1 we decided to do immuno-histochemical (IHC) staining for Ber-EP4 (to rule out PA). IHC stain for Ber-EP4 showed positive staining for the lesional cells of invading islands. (Figure-3). Based on IHC profile, a final diagnosis of mucosal basal cell carcinoma was rendered. One year follow up of the patient is uneventful
Dr. Manas Bajpai, , Nilesh Pardhe, , Manika Arora. (2016) INTRA-ORAL BASAL CELL CARCINOMA-AN IMMUNOHISTOCHEMICAL INTERPRETATION USING BER–EP4, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 28, Issue 2.
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